Research Article
Open Access
Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives as Anti-Tuberculosis Agents
Vaibhav Jain1, Priyal Jain2, Dr. Surendra Jain3
1Mhatma Jyoti Rao Phoole University Jaipur, Rajasthan, India
2Mhatma Jyoti Rao Phoole University Jaipur, Rajasthan, India.
3Sagar Institute of Research & Technology-Pharmacy, Bhopal, MP, India
2Mhatma Jyoti Rao Phoole University Jaipur, Rajasthan, India.
3Sagar Institute of Research & Technology-Pharmacy, Bhopal, MP, India
Vaibhav Jain et al /Int.J. TechnoChem Res. 2019,5(1),pp 56-60.
Abstract
In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-
5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with
hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-
5(4H)-one was alkylated with different halogenated alkylated substituted chain in the
presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR
spectroscopy data and elemental analysis. The antitubercular activity of these compounds were
evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M.
Tuberculosis compared with standard INH, RIF & ETM.
5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with
hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-
5(4H)-one was alkylated with different halogenated alkylated substituted chain in the
presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR
spectroscopy data and elemental analysis. The antitubercular activity of these compounds were
evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M.
Tuberculosis compared with standard INH, RIF & ETM.
Keywords
Antituberculosis, Isoniazid, Rifampicin, Pyrazoline.
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